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The elucidation of phospholipid bilayer-small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques

Townshend, Georgina, Thompson, Gary, White, Lisa J., Hiscock, Jennifer R., Ortega-Roldan, Jose L. (2020) The elucidation of phospholipid bilayer-small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques. Chemical Communications, . ISSN 1359-7345. (doi:10.1039/C9CC09948D) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:80365)

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Abstract

Quantifying phospholipid bilayer-small molecule interactions is vital to the development of new drug candidates and/or medicinal therapies. However, obtaining these data remains problematic. Herein, we detail a phospholipid nanodisc assay which enables the elucidation of these interactions using conventional solution state NMR spectroscopy techniques.

Item Type: Article
DOI/Identification number: 10.1039/C9CC09948D
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Faculties > Sciences > School of Physical Sciences
Depositing User: Jennifer Hiscock
Date Deposited: 05 Mar 2020 18:04 UTC
Last Modified: 06 Mar 2020 11:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/80365 (The current URI for this page, for reference purposes)
Thompson, Gary: https://orcid.org/0000-0001-9399-7636
Hiscock, Jennifer R.: https://orcid.org/0000-0002-1406-8802
Ortega-Roldan, Jose L.: https://orcid.org/0000-0002-6316-4390
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