The elucidation of phospholipid bilayer-small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques

Townshend, Georgina, Thompson, Gary, White, Lisa J., Hiscock, Jennifer R., Ortega-Roldan, Jose L. (2020) The elucidation of phospholipid bilayer-small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques. Chemical Communications, . ISSN 1359-7345. (doi:10.1039/C9CC09948D) (KAR id:80365)

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Official URL: https://doi.org/10.1039/C9CC09948D

Abstract

Quantifying phospholipid bilayer-small molecule interactions is vital to the development of new drug candidates and/or medicinal therapies. However, obtaining these data remains problematic. Herein, we detail a phospholipid nanodisc assay which enables the elucidation of these interactions using conventional solution state NMR spectroscopy techniques.

Item Type:	Article
DOI/Identification number:	10.1039/C9CC09948D
Subjects:	Q Science
Divisions:	Divisions > Division of Natural Sciences > Biosciences Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User:	Jennifer Hiscock
Date Deposited:	05 Mar 2020 18:04 UTC
Last Modified:	05 Nov 2024 12:46 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/80365 (The current URI for this page, for reference purposes)

University of Kent Author Information

Townshend, Georgina.

Creator's ORCID:
CReDIT Contributor Roles:

Thompson, Gary.

Creator's ORCID:	https://orcid.org/0000-0001-9399-7636
CReDIT Contributor Roles:

Hiscock, Jennifer R..

Creator's ORCID:	https://orcid.org/0000-0002-1406-8802
CReDIT Contributor Roles:

Ortega-Roldan, Jose L..

Creator's ORCID:	https://orcid.org/0000-0002-6316-4390
CReDIT Contributor Roles:

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