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Form from Function, Order from Chaos in Male Germline Chromatin

Ellis, Peter J.I., Griffin, Darren K. (2020) Form from Function, Order from Chaos in Male Germline Chromatin. Genes, 11 (2). ISSN 2073-4425. (doi:10.3390/genes11020210) (KAR id:80218)

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https://doi.org/10.3390/genes11020210

Abstract

Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving co-ordinated waves of DNA methylation and demethylation, histone modification, replacement and removal occurring before, during and after meiosis. This Special Issue has drawn together papers addressing many aspects of chromatin organization and dynamics in the male germ line, in humans and in model organisms. Two major themes emerge from these studies: the first is the functional significance of nuclear organisation in the developing germline; the second is the interplay between sperm chromatin structure and susceptibility to DNA damage and mutation. The consequences of these aspects for fertility, both in humans and other animals, is a major health and social welfare issue and this is reflected in these nine exciting manuscripts.

Item Type: Article
DOI/Identification number: 10.3390/genes11020210
Uncontrolled keywords: spermatogenesis; chromatin; nuclear organisation; DNA oxidation; DNA fragmentation; epigenetic inheritance; histone retention; assisted reproduction; in vitro fertilisation
Subjects: Q Science > QP Physiology (Living systems)
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Darren Griffin
Date Deposited: 24 Feb 2020 16:34 UTC
Last Modified: 25 Feb 2020 08:54 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/80218 (The current URI for this page, for reference purposes)
Ellis, Peter J.I.: https://orcid.org/0000-0001-9709-7934
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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