Ellis, Peter J.I., Griffin, Darren K. (2020) Form from Function, Order from Chaos in Male Germline Chromatin. Genes, 11 (2). Article Number 210. ISSN 2073-4425. (doi:10.3390/genes11020210) (KAR id:80218)
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Official URL: https://doi.org/10.3390/genes11020210 |
Abstract
Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving co-ordinated waves of DNA methylation and demethylation, histone modification, replacement and removal occurring before, during and after meiosis. This Special Issue has drawn together papers addressing many aspects of chromatin organization and dynamics in the male germ line, in humans and in model organisms. Two major themes emerge from these studies: the first is the functional significance of nuclear organisation in the developing germline; the second is the interplay between sperm chromatin structure and susceptibility to DNA damage and mutation. The consequences of these aspects for fertility, both in humans and other animals, is a major health and social welfare issue and this is reflected in these nine exciting manuscripts.
Item Type: | Article |
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DOI/Identification number: | 10.3390/genes11020210 |
Uncontrolled keywords: | spermatogenesis; chromatin; nuclear organisation; DNA oxidation; DNA fragmentation; epigenetic inheritance; histone retention; assisted reproduction; in vitro fertilisation |
Subjects: | Q Science > QP Physiology (Living systems) |
Divisions: | Divisions > Division of Natural Sciences > Biosciences |
Depositing User: | Darren Griffin |
Date Deposited: | 24 Feb 2020 16:34 UTC |
Last Modified: | 05 Nov 2024 12:45 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/80218 (The current URI for this page, for reference purposes) |
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