Molecular and functional definition of the developing human striatum

Onorati, Marco, Castiglioni, Valentina, Biasci, Daniele, Cesana, Elisabetta, Menon, Ramesh, Vuono, Romina, Talpo, Francesca, Laguna Goya, Rocio, Lyons, Paul A, Bulfamante, Gaetano P, and others. (2014) Molecular and functional definition of the developing human striatum. Nature Neuroscience, 17 (12). pp. 1804-1815. ISSN 1097-6256. (doi:10.1038/nn.3860) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78974)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: https://doi.org/10.1038/nn.3860

Abstract

The complexity of the human brain derives from the intricate interplay of molecular instructions during development. Here we systematically investigated gene expression changes in the prenatal human striatum and cerebral cortex during development from post-conception weeks 2 to 20. We identified tissue-specific gene coexpression networks, differentially expressed genes and a minimal set of bimodal genes, including those encoding transcription factors, that distinguished striatal from neocortical identities. Unexpected differences from mouse striatal development were discovered. We monitored 36 determinants at the protein level, revealing regional domains of expression and their refinement, during striatal development. We electrophysiologically profiled human striatal neurons differentiated in vitro and determined their refined molecular and functional properties. These results provide a resource and opportunity to gain global understanding of how transcriptional and functional processes converge to specify human striatal and neocortical neurons during development.

Item Type:	Article
DOI/Identification number:	10.1038/nn.3860
Divisions:	Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User:	Romina Vuono
Date Deposited:	25 Nov 2019 16:04 UTC
Last Modified:	17 Aug 2022 11:02 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/78974 (The current URI for this page, for reference purposes)

University of Kent Author Information

Vuono, Romina.

Creator's ORCID:	https://orcid.org/0000-0002-5162-3422
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