Suppression of neointimal hyperplasia by photodynamic therapy: in vitro and in vivo results

Sobeh, Mohammed S., Chan, P., Greenwald, Stephen E., Ham, Robert J., Wood, Alan J., Cross, Frank W., Hsiang, York N. (1994) Suppression of neointimal hyperplasia by photodynamic therapy: in vitro and in vivo results. In: Proceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV. Diagnostic and Therapeutic Cardiovascular Interventions IV. . pp. 47-52. SPIE (doi:10.1117/12.179929) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78349)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: https://doi.org/10.1117/12.179929

Abstract

Proliferation of vascular smooth muscle cells (VSMCs) is the pathophysiogical basis of the restenoses which occur in 30-55% of patients undergone revascularisation. Prophylactic measures including pharmacotherapy, endovascular stenting and anti-gene therapy have so far failed to contain this problem. Photodynamic therapy (PDT) may selectively suppress VSMCs and decrease restenosis rates. We report 2 studies; the first examines the effect of PDT on an in-vitro model of NIH and the second involves using endoluminal ablation of an in-vivo model of experimental NIH of the rabbit's aorta.

Item Type:	Conference or workshop item (Proceeding)
DOI/Identification number:	10.1117/12.179929
Uncontrolled keywords:	Blood vessels, Cardiovascular system, Cells, Muscle, Atherosclerosis, Neointimal hyperplasia, Restenosis, Revascularization, Vascular smooth muscle cells, Photodynamic therapy
Institutional Unit:	Schools > Kent and Medway Medical School
Former Institutional Unit:	Divisions > Division of Natural Sciences > Kent and Medway Medical School
Depositing User:	Philip Chan
Date Deposited:	07 Nov 2019 16:58 UTC
Last Modified:	20 May 2025 09:58 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/78349 (The current URI for this page, for reference purposes)

University of Kent Author Information

Chan, P..

Creator's ORCID:	https://orcid.org/0000-0001-9780-140X
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