Baker, Karen, Gyamfi, Irene A., Mashanov, Gregory I., Molloy, Justin E., Geeves, Michael A., Mulvihill, Daniel P. (2019) TORC2-Gad8 dependent myosin phosphorylation modulates regulation by calcium. eLife, 8 . E-ISSN 2050-084X. (doi:10.7554/eLife.51150) (KAR id:76937)
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Official URL: https://dx.doi.org/10.7554/eLife.51150 |
Resource title: | TORC2-Gad8 dependent myosin phosphorylation modulates regulation by calcium |
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Resource type: | Dataset |
DOI: | 10.22024/UniKent/01.01.60 |
KDR/KAR URL: | http://data.kent.ac.uk/60/ |
External URL: |
Abstract
Cells respond to changes in their environment through signalling networks that modulate cytoskeleton and membrane organisation to coordinate cell cycle progression, polarised cell growth and multicellular development. Here, we define a novel regulatory mechanism by which the motor activity and function of the fission yeast type 1 myosin, Myo1, is modulated by TORC2 signalling dependent phosphorylation. Phosphorylation of the conserved serine at position 742 within the neck region changes both the conformation of the neck region and the interactions between Myo1 and its associating calmodulin light chains. S742 phosphorylation thereby couples calcium and TOR signalling networks in the modulation of myosin-1 dynamics to co-ordinate actin polymerisation and membrane reorganisation at sites of endocytosis and polarised cell growth in response to environmental and cell cycle cues.
Item Type: | Article |
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DOI/Identification number: | 10.7554/eLife.51150 |
Uncontrolled keywords: | pombe, endocytosis, calmodulin, Tor kinase |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Divisions > Division of Natural Sciences > Biosciences |
Depositing User: | Daniel Mulvihill |
Date Deposited: | 01 Oct 2019 09:35 UTC |
Last Modified: | 05 Nov 2024 12:41 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/76937 (The current URI for this page, for reference purposes) |
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