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Damage to amino acid-nucleotide pairs induced by 1 eV electrons

Ptasińska, S., Li, Z., Mason, Nigel, Sanche, L. (2010) Damage to amino acid-nucleotide pairs induced by 1 eV electrons. Physical Chemistry Chemical Physics, 12 (32). pp. 9367-9372. (doi:10.1039/b926267a) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:74764)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1039/b926267a

Abstract

We have investigated the role of two selected amino acids, glycine and arginine, on damage induced to a short chain of single stranded DNA, the tetramer GCAT, during 1 eV electron exposure. At this energy, DNA has a high cross section for DNA damage via exclusively dissociative electron attachment. Surprisingly, at low ratios of glycine:GCAT, an increase in the total fragmentation yield is observed, whilst at higher ratios, glycine and arginine appear to protect DNA from the direct action of electrons. In addition, binding energies were calculated by molecular modelling of the interactions between these amino acids and either nucleobases or nucleotides. These binding energies appear to be related to the ability of amino acids to protect DNA against low energy electron damage.

Item Type: Article
DOI/Identification number: 10.1039/b926267a
Uncontrolled keywords: amino acid, single stranded DNA, article, chemistry, DNA damage, electron, ionizing radiation, nucleotide sequence, thermodynamics, Amino Acids, Base Sequence, DNA Damage, DNA, Single-Stranded, Electrons, Radiation, Ionizing, Thermodynamics
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User: Nigel Mason
Date Deposited: 18 Jul 2019 13:37 UTC
Last Modified: 16 Nov 2021 10:26 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/74764 (The current URI for this page, for reference purposes)

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