Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape

Sakhnevych, Svetlana S., Yasinska, Inna M., Fasler-Kan, Elizaveta, Sumbayev, Vadim V. (2019) Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape. Frontiers in Pharmacology, 10 . ISSN 1663-9812. (doi:10.3389/fphar.2019.00342) (KAR id:74463)

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Official URL: https://doi.org/10.3389/fphar.2019.00342

Abstract

The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer

cells against host immune surveillance. We found that pharmacologically induced

mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human

colorectal cancer cells and re-distribution of this protein (the effect described for various

cellular proteins) into mitochondria.

Item Type:	Article
DOI/Identification number:	10.3389/fphar.2019.00342
Uncontrolled keywords:	galectin-9, Tim-3, immune surveillance, mitochondria, colorectal cancer
Institutional Unit:	Schools > Medway School of Pharmacy
Former Institutional Unit:	Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User:	Vadim Sumbayev
Date Deposited:	19 Jun 2019 09:53 UTC
Last Modified:	22 Jul 2025 09:00 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/74463 (The current URI for this page, for reference purposes)

University of Kent Author Information

Yasinska, Inna M..

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CReDIT Contributor Roles:

Sumbayev, Vadim V..

Creator's ORCID:	https://orcid.org/0000-0002-9404-5626
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