Ezcurra, Marina, Benedetto, Alexandre, Sornda, Thanet, Gilliat, Ann F., Au, Catherine, Zhang, Qifeng, van Schelt, Sophie, Petrache, Alexandra L., Wang, Hongyuan, de la Guardia, Yila, and others. (2018) C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies. Current Biology, 28 (16). pp. 2544-2556. ISSN 0960-9822. E-ISSN 1879-0445. (doi:10.1016/j.cub.2018.06.035) (KAR id:74206)
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| Official URL: https://doi.org/10.1016/j.cub.2018.06.035 |
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Abstract
Aging (senescence) is characterized by the development of numerous pathologies, some of which limit lifespan. Key to understanding aging is discovery of the mechanisms (etiologies) that cause
senescent pathology. In C. elegans a major senescent pathology of unknown etiology is atrophy of its principal metabolic organ, the intestine. Here we identify a cause of not only this pathology,
but also of yolky lipid accumulation and redistribution (a form of senescent obesity): autophagymediated conversion of intestinal biomass into yolk. Inhibiting intestinal autophagy or vitellogenesis rescues both visceral pathologies and can also extend lifespan. This defines a disease syndrome leading to multimorbidity and contributing to late-life mortality. Activation of gut-toyolk biomass conversion by insulin/IGF-1 signaling (IIS) promotes reproduction and senescence. This illustrates how major, IIS-promoted senescent pathologies in C. elegans can originate not
from damage accumulation, but from direct effects of futile, continued action of a wild-type biological program (vitellogenesis).
| Item Type: | Article |
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| DOI/Identification number: | 10.1016/j.cub.2018.06.035 |
| Uncontrolled keywords: | aginga, trophy, autophagy, C. elegans, intestine, insulin/IGF-1 signaling, pathology, steatosis, vitellogenin, yolk, School of Biosciences |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Marina Ezcurra |
| Date Deposited: | 31 May 2019 15:00 UTC |
| Last Modified: | 05 Nov 2024 12:37 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/74206 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Ezcurra, Marina.
| Creator's ORCID: |
 https://orcid.org/0000-0003-2739-6984
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