Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032

Riedlinger, Julia, Reicke, Andreas, Zahner, Hans, Krismer, B., Bull, Alan T., Maldonado, Luis A., Ward, Alan C., Goodfellow, Michael, Bister, Bojan, Bischoff, Daniel, and others. (2004) Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032. Journal of Antibiotics, 57 (4). pp. 271-279. ISSN 0021-8820. (doi:10.7164/antibiotics.57.271) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:7347)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: https://doi.org/10.7164/antibiotics.57.271

Abstract

A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.

Item Type:	Article
DOI/Identification number:	10.7164/antibiotics.57.271
Additional information:	Article 823WD English Times Cited:28 Cited References Count:23
Uncontrolled keywords:	antibiotics, tetronic acid, structure elucidation, abyssomicins, Verrucosispora
Subjects:	Q Science
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Susan Davies
Date Deposited:	03 Oct 2008 15:24 UTC
Last Modified:	05 Nov 2024 09:39 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/7347 (The current URI for this page, for reference purposes)

University of Kent Author Information

Bull, Alan T..

Creator's ORCID:	https://orcid.org/0000-0001-6223-7722
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