Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14

Bringmann, Gerhard, Lang, Gerhard, Maksimenka, Katja, Hamm, Andreas, Gulder, Tobias A. M., Dieter, Anke, Bull, Alan T., Stach, James E.M., Kocher, Niko, Muller, Werner E. G., and others. (2005) Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14. Phytochemistry, 66 (11). pp. 1366-1373. ISSN 0031-9422. (doi:10.1016/j.phytochem.2005.04.010) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:7345)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1016/j.phytochem.2005.04.010

Abstract

The new, highly oxygenated angucyclinone gephyromycin was isolated from an extract of a Streptomyces griseus strain. Its unprecedented ether-bridged structure was elucidated by NMR methods and substantiated by single crystal X-ray analysis. The absolute configuration was evidenced by quantum chemical CD calculations. Gephyromycin exhibits glutaminergic activity towards neuronal cells. Furthermore, the known compounds fridamycin E and dehydrorabelomycin were identified. (c) 2005 Elsevier Ltd. All rights reserved.

Item Type:	Article
DOI/Identification number:	10.1016/j.phytochem.2005.04.010
Additional information:	Article 947FM English Times Cited:2 Cited References Count:29
Uncontrolled keywords:	Streptomyces angucyclinones natural products secondary metabolites glutaminergic activity circular dichroism (CD) quantum chemical CD calculations X-ray structure analysis ANTIBIOTICS URDAMYCINS MECHANISMS FLUPIRTINE
Subjects:	Q Science
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Susan Davies
Date Deposited:	05 Sep 2008 15:44 UTC
Last Modified:	05 Nov 2024 09:39 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/7345 (The current URI for this page, for reference purposes)

University of Kent Author Information

Bull, Alan T..

Creator's ORCID:	https://orcid.org/0000-0001-6223-7722
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