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Genome-wide association studies targeting the yield of extraembryonic fluid and production traits in Russian White chickens

Kudinov, Andrei A, Dementieva, N V, Mitrofanova, Olga V, Stanishevskaya, Olga I, Fedorova, Elena S, Larkina, T A, Mishina, Arina I, Plemyashov, Kirill V, Griffin, Darren K., Romanov, Michael N and others. (2019) Genome-wide association studies targeting the yield of extraembryonic fluid and production traits in Russian White chickens. BMC Genomics, 20 (1). p. 270. ISSN 1471-2164. E-ISSN 1471-2164. (doi:10.1186/s12864-019-5605-5)

Abstract

Background: The Russian White is a gene pool breed, registered in 1953 after crossing White Leghorns with local populations and, for 50 years, selected for cold tolerance and high egg production (EL). The breed has great potential in meeting demands of local food producers, commercial farmers and biotechnology sector of specific pathogen-free (SPF) eggs, the former valuing the breed for its egg weight (EW), EL, age at first egg (AFE), body weight (BW), and the latter for its yield of extraembryonic fluid (YEF) in 12.5-day embryos, ratio of extraembryonic fluid to egg weight, and embryo mass. Moreover, its cold tolerance has been presumably associated with day-old chick down colour (DOCDC) – white rather than yellow, the genetic basis of these traits being however poorly understood. Results: We undertook genome-wide association studies (GWASs) for eight performance traits using single nucleotide polymorphism (SNP) genotyping of 146 birds and an Illumina 60KBeadChip. Several suggestive associations (p < 5.16*10− 5) were found for YEF, AFE, BW and EW. Moreover, on chromosome 2, an association with the white DOCDC was found where there is an linkage disequilibrium block of SNPs including genes that are responsible not for colour, but for immune resistance. Conclusions: The obtained GWAS data can be used to explore the genetics of immunity and carry out selection for increasing YEF for SPF eggs production.

Item Type: Article
DOI/Identification number: 10.1186/s12864-019-5605-5
Uncontrolled keywords: GWAS, Russian white chicken breed, Poultry, Day-old chick down colour, Yield of extraembryonic fluid, SNP
Subjects: Q Science > QH Natural history > QH426 Genetics
S Agriculture > SF Animal husbandry
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: M. Romanov
Date Deposited: 05 Apr 2019 16:26 UTC
Last Modified: 11 Jul 2019 09:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/73388 (The current URI for this page, for reference purposes)
Kudinov, Andrei A: https://orcid.org/0000-0002-7811-576X
Mitrofanova, Olga V: https://orcid.org/0000-0003-4702-2736
Stanishevskaya, Olga I: https://orcid.org/0000-0001-9504-3916
Fedorova, Elena S: https://orcid.org/0000-0002-1618-6271
Plemyashov, Kirill V: https://orcid.org/0000-0002-3658-5886
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
Romanov, Michael N: https://orcid.org/0000-0003-3584-4644
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