Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora

Fiedler, Hans-Peter and Bruntner, Christina and Riedlinger, Julia and Bull, Alan T. and Knutsen, Gjert and Goodfellow, Michael and Jones, Amanda L. and Maldonado, Luis A. and Pathom-aree, Wasu and Beil, Winfried and Schneider, Kathrin and Keller, Simone and Sussmuth, Roderich D. (2008) Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora. Journal of Antibiotics, 61 (3). pp. 158-163. ISSN 0021-8820 . (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Abstract

A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.

Item Type: Article
Additional information: Article 287UL English Times Cited:0 Cited References Count:15
Uncontrolled keywords: aminofuran antibiotics antitumor activity marine actinomycetes Verrucosispora physico-chemical properties proximicin A proximicin B proximicin C
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Sue Davies
Date Deposited: 14 Mar 2009 10:17
Last Modified: 01 May 2014 15:14
Resource URI: https://kar.kent.ac.uk/id/eprint/7332 (The current URI for this page, for reference purposes)
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