Fiedler, Hans-Peter, Bruntner, Christina, Riedlinger, Julia, Bull, Alan T., Knutsen, Gjert, Goodfellow, Michael, Jones, Amanda L., Maldonado, Luis A., Pathom-aree, Wasu, Beil, Winfried, and others. (2008) Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora. Journal of Antibiotics, 61 (3). pp. 158-163. ISSN 0021-8820. (doi:10.1038/ja.2008.125) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:7332)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... |
Abstract
A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1038/ja.2008.125 |
| Additional information: | Article 287UL English Times Cited:0 Cited References Count:15 |
| Uncontrolled keywords: | aminofuran antibiotics antitumor activity marine actinomycetes Verrucosispora physico-chemical properties proximicin A proximicin B proximicin C |
| Subjects: | Q Science |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Susan Davies |
| Date Deposited: | 14 Mar 2009 10:17 UTC |
| Last Modified: | 05 Nov 2024 09:39 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/7332 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Bull, Alan T..
| Creator's ORCID: |
 https://orcid.org/0000-0001-6223-7722
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