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Effect of aspirin on mitochondrial mutagens in Saccharomyces cerevisiae

Bruce, Ian J., Wilkie, David (1984) Effect of aspirin on mitochondrial mutagens in Saccharomyces cerevisiae. MGG Molecular & General Genetics, 194 (1-2). pp. 299-302. ISSN 0026-8925. (doi:10.1007/BF00383531) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:72151)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1007/BF00383531

Abstract

The mitochondrial mutation petite was induced in yeast cells by ethidium bromide (EB), Adriamycin (ADR) and 4-nitroquinoline-N-oxide (NQO). In the presence of aspirin in concentrations ranging from 0.1 to 1.0 mg/ml, the mutagenicity of EB and ADR was reversed but petite induction by NQO was unaffected. At these concentrations, aspirin also reversed mitochondrial inhibition by oligomycin, a non-mutagenic inhibitor of the organellar ATPase complex.

Cells grown in the presence of aspirin alone showed a significantly higher rate of oxygen uptake than untreated control cultures when the drug concentration ranged from 0.05 to 1.0 mg/ml. At concentrations of 2 mg/ml and above, aspirin inhibited mitochondrial respiration.

Item Type: Article
DOI/Identification number: 10.1007/BF00383531
Uncontrolled keywords: Aspirin, Respiration, Drug Concentration, Yeast Cell, Ethidium Bromide
Divisions: Faculties > Sciences > School of Physical Sciences
Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Ian Bruce
Date Deposited: 04 Feb 2019 15:42 UTC
Last Modified: 30 May 2019 08:52 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/72151 (The current URI for this page, for reference purposes)
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