Bruce, Ian J., Wilkie, David (1984) Effect of aspirin on mitochondrial mutagens in Saccharomyces cerevisiae. MGG Molecular & General Genetics, 194 (1-2). pp. 299-302. ISSN 0026-8925. (doi:10.1007/BF00383531) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:72151)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: https://doi.org/10.1007/BF00383531 |
Abstract
The mitochondrial mutation petite was induced in yeast cells by ethidium bromide (EB), Adriamycin (ADR) and 4-nitroquinoline-N-oxide (NQO). In the presence of aspirin in concentrations ranging from 0.1 to 1.0 mg/ml, the mutagenicity of EB and ADR was reversed but petite induction by NQO was unaffected. At these concentrations, aspirin also reversed mitochondrial inhibition by oligomycin, a non-mutagenic inhibitor of the organellar ATPase complex.
Cells grown in the presence of aspirin alone showed a significantly higher rate of oxygen uptake than untreated control cultures when the drug concentration ranged from 0.05 to 1.0 mg/ml. At concentrations of 2 mg/ml and above, aspirin inhibited mitochondrial respiration.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1007/BF00383531 |
| Uncontrolled keywords: | Aspirin, Respiration, Drug Concentration, Yeast Cell, Ethidium Bromide |
| Divisions: | Divisions > Division of Natural Sciences > Physics and Astronomy |
| Depositing User: | Ian Bruce |
| Date Deposited: | 04 Feb 2019 15:42 UTC |
| Last Modified: | 05 Nov 2024 12:34 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/72151 (The current URI for this page, for reference purposes) |
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