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Metal binding precursors for the synthesis of peptide-metal conjugates.

Blower, P.J. & Greenland, W.E.P. (2006) Metal binding precursors for the synthesis of peptide-metal conjugates. US2006111552. (doi:US2006111552) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:7193)

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Abstract

Specific metal-chelating precursors incorporating a pendant protected (e.g. with Fmoc) amino acid functionality are synthesised. The pendant amino acid functionality allows the chelator to be inserted into a synthetic peptide sequence during standard solid-phase peptide synthesis at any predetermined position in the sequence, in place of lysine or any other amino acid, or in addition to native amino acids. An example is a conjugate incorporating Fmoc-protected L-lysine and the technetium-binding group hynic (hydrazinonicotinamide), shown as molecule 1 in FIG. 1 of the accompanying drawing. These molecules permit synthetic approaches with greater flexibility and control of the site of labelling than conventional methods. They are particularly suited to development of combinatorial libraries of radiolabelled peptides, which will be especially significant in the development of radiopharmaceuticals targeted towards the many new cancer-related targets likely to be identified in the near future through developments in proteomics.

Item Type: Patent
DOI/Identification number: US2006111552
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Susan Davies
Date Deposited: 12 Sep 2008 20:35 UTC
Last Modified: 16 Nov 2021 09:45 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/7193 (The current URI for this page, for reference purposes)

University of Kent Author Information

Blower, Philip J..

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