Structure Determination and MSn Analysis of Two New Lissoclinamides Isolated from the Indo–Pacific Ascidian Lissoclinum patella: NOE Restrained Molecular Dynamics Confirms the Absolute Stereochemistry Derived by Degradative Methods

Morris, LA, Jantina Kettenes van den Bosch, J, Versluis, K, Thompson, GS, Jaspars, M (2000) Structure Determination and MSn Analysis of Two New Lissoclinamides Isolated from the Indo–Pacific Ascidian Lissoclinum patella: NOE Restrained Molecular Dynamics Confirms the Absolute Stereochemistry Derived by Degradative Methods. Tetrahedron, 56 . pp. 8345-8353. ISSN 0040-4020. (doi:10.1016/S0040-4020(00)00746-8) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:71827)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1016/S0040-4020(00)00746-8

Abstract

Two new lissoclinamides, lissoclinamides 9 and 10 were isolated from an Indonesian collection of the ascidian Lissoclinum patella along with the known patellamide C. The structures of the lissoclinamides were determined by a combination of 2D NMR, selective 1D TOCSY, MS and MSn techniques. The assignment of absolute stereochemistry was achieved by the hydrolysis of lissoclinamides 9 and 10 followed by chiral TLC. In the case of lissoclinamide 9, NOE restrained molecular dynamics studies were also performed confirming the proposed stereochemistry.

Item Type:	Article
DOI/Identification number:	10.1016/S0040-4020(00)00746-8
Subjects:	Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Gary Thompson
Date Deposited:	23 Jan 2019 16:29 UTC
Last Modified:	05 Nov 2024 12:34 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/71827 (The current URI for this page, for reference purposes)

University of Kent Author Information

Thompson, GS.

Creator's ORCID:	https://orcid.org/0000-0001-9399-7636
CReDIT Contributor Roles:

Depositors only (login required):

Altmetric

Download Statistics

Total unique views for this document in KAR since July 2020. For more details click on the image.