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Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE1-34

Houssen, WE, Wright, SH, Kalverda, AP, Thompson, GS, Kelly, SM, Jaspars, M (2010) Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE1-34. ChemBioChem, 11 . pp. 1867-1873. ISSN 1439-4227. (doi:10.1002/cbic.201000305) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1002/cbic.201000305

Abstract

The solution structure of the leader sequence of the patellamide precursor peptide was analysed by using CD and determined with NOE-restrained molecular dynamics calculations. This leader sequence is highly conserved in the precursor peptides of some other cyanobactins harbouring heterocycles, and is assumed to play a role in targeting the precursor peptide to the post-translational machinery. The sequence was observed to form an alpha-helix spanning residues 13-28 with a hydrophobic surface on one side of the helix. This hydrophobic surface is proposed to be the site of the initial binding with modifying enzymes.

Item Type: Article
DOI/Identification number: 10.1002/cbic.201000305
Subjects: Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: G. Thompson
Date Deposited: 23 Jan 2019 17:51 UTC
Last Modified: 30 May 2019 08:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/71813 (The current URI for this page, for reference purposes)
Thompson, GS: https://orcid.org/0000-0001-9399-7636
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