Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE1-34

Houssen, WE, Wright, SH, Kalverda, AP, Thompson, GS, Kelly, SM, Jaspars, M (2010) Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE1-34. ChemBioChem, 11 . pp. 1867-1873. ISSN 1439-4227. (doi:10.1002/cbic.201000305) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:71813)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org/10.1002/cbic.201000305

Abstract

The solution structure of the leader sequence of the patellamide precursor peptide was analysed by using CD and determined with NOE-restrained molecular dynamics calculations. This leader sequence is highly conserved in the precursor peptides of some other cyanobactins harbouring heterocycles, and is assumed to play a role in targeting the precursor peptide to the post-translational machinery. The sequence was observed to form an alpha-helix spanning residues 13-28 with a hydrophobic surface on one side of the helix. This hydrophobic surface is proposed to be the site of the initial binding with modifying enzymes.

Item Type:	Article
DOI/Identification number:	10.1002/cbic.201000305
Subjects:	Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Institutional Unit:	Schools > School of Natural Sciences > Biosciences
Former Institutional Unit:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Gary Thompson
Date Deposited:	23 Jan 2019 17:51 UTC
Last Modified:	20 May 2025 09:23 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/71813 (The current URI for this page, for reference purposes)

University of Kent Author Information

Thompson, GS.

Creator's ORCID:	https://orcid.org/0000-0001-9399-7636
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