Houssen, WE, Wright, SH, Kalverda, AP, Thompson, GS, Kelly, SM, Jaspars, M (2010) Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE1-34. ChemBioChem, 11 . pp. 1867-1873. ISSN 1439-4227. (doi:10.1002/cbic.201000305) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:71813)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org/10.1002/cbic.201000305 |
Abstract
The solution structure of the leader sequence of the patellamide precursor peptide was analysed by using CD and determined with NOE-restrained molecular dynamics calculations. This leader sequence is highly conserved in the precursor peptides of some other cyanobactins harbouring heterocycles, and is assumed to play a role in targeting the precursor peptide to the post-translational machinery. The sequence was observed to form an alpha-helix spanning residues 13-28 with a hydrophobic surface on one side of the helix. This hydrophobic surface is proposed to be the site of the initial binding with modifying enzymes.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1002/cbic.201000305 |
| Subjects: | Q Science > QP Physiology (Living systems) > QP517 Biochemistry |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Gary Thompson |
| Date Deposited: | 23 Jan 2019 17:51 UTC |
| Last Modified: | 16 Nov 2021 10:26 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/71813 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Thompson, GS.
| Creator's ORCID: |
 https://orcid.org/0000-0001-9399-7636
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|---|---|
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