Skip to main content
Kent Academic Repository

Between-host evolution of mutation-rate and within-host evolution of virulence

Johnson, Colin G. (1998) Between-host evolution of mutation-rate and within-host evolution of virulence. In: Proceedings Third German Workshop on Artificial Life. . Harri Deutsch (KAR id:71010)

Abstract

It has been recently realised that parasite virulence (the harm caused by parasites to their hosts) can be an adaptive trait. Selection for a particular level of virulence can happen either at the level of between-host tradeoffs or as a result of short-sighted within-host competition. This paper describes some simulations which study the effect that modifier genes for changes in mutation rate have on suppressing this short-sighted development of virulence, and investigates the interaction between this and a simplified model of immune clearance.

Item Type: Conference or workshop item (Paper)
Subjects: Q Science > QA Mathematics (inc Computing science) > QA 76 Software, computer programming,
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User: Colin Johnson
Date Deposited: 13 Dec 2018 16:24 UTC
Last Modified: 16 Nov 2021 10:25 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/71010 (The current URI for this page, for reference purposes)

University of Kent Author Information

  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.