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Between-host evolution of mutation-rate and within-host evolution of virulence

Johnson, Colin G. (1998) Between-host evolution of mutation-rate and within-host evolution of virulence. In: Proceedings Third German Workshop on Artificial Life. . Harri Deutsch

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Abstract

It has been recently realised that parasite virulence (the harm caused by parasites to their hosts) can be an adaptive trait. Selection for a particular level of virulence can happen either at the level of between-host tradeoffs or as a result of short-sighted within-host competition. This paper describes some simulations which study the effect that modifier genes for changes in mutation rate have on suppressing this short-sighted development of virulence, and investigates the interaction between this and a simplified model of immune clearance.

Item Type: Conference or workshop item (Paper)
Subjects: Q Science > QA Mathematics (inc Computing science) > QA 76 Software, computer programming,
Divisions: Faculties > Sciences > School of Computing
Depositing User: Colin Johnson
Date Deposited: 13 Dec 2018 16:24 UTC
Last Modified: 30 May 2019 08:34 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/71010 (The current URI for this page, for reference purposes)
Johnson, Colin G.: https://orcid.org/0000-0002-9236-6581
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