Towards predictable transmembrane transport: QSAR analysis of anion binding and transport

Basschaert, Natalie, Bradberry, S. J., Wenzel, Marco, Haynes, Cally J. E., Hiscock, Jennifer R., Kirby, Isabelle L., Karagiannidis, Louise E., Moore, Stephen J., Wells, Neil J., Herniman, J., and others. (2013) Towards predictable transmembrane transport: QSAR analysis of anion binding and transport. Chemical Science, 4 (8). pp. 3036-3045. ISSN 2041-6520. (doi:10.1039/C3SC51023A) (KAR id:70832)

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Official URL: http://dx.doi.org/10.1039/C3SC51023A

Abstract

The transport of anions across biological membranes by small molecules is a growing research field due to the potential therapeutic benefits of these compounds. However, little is known about the exact mechanism by which these drug-like molecules work and which molecular features make a good transporter. An extended series of 1-hexyl-3-phenylthioureas were synthesized, fully characterized (NMR, mass spectrometry, IR and single crystal diffraction) and their anion binding and anion transport properties were assessed using 1H NMR titration techniques and a variety of vesicle-based experiments. Quantitative structure–activity relationship (QSAR) analysis revealed that the anion binding abilities of the mono-thioureas are dominated by the (hydrogen bond) acidity of the thiourea NH function. Furthermore, mathematical models show that the experimental transmembrane anion transport ability is mainly dependent on the lipophilicity of the transporter (partitioning into the membrane), but smaller contributions of molecular size (diffusion) and hydrogen bond acidity (anion binding) were also present. Finally, we provide the first step towards predictable anion transport by employing the QSAR equations to estimate the transmembrane transport ability of four new compounds.

Item Type:	Article
DOI/Identification number:	10.1039/C3SC51023A
Subjects:	Q Science > QD Chemistry
Divisions:	Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User:	Jennifer Hiscock
Date Deposited:	07 Dec 2018 16:53 UTC
Last Modified:	05 Nov 2024 12:33 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/70832 (The current URI for this page, for reference purposes)

University of Kent Author Information

Hiscock, Jennifer R..

Creator's ORCID:	https://orcid.org/0000-0002-1406-8802
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