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A Symbiotic Supramolecular Approach to the Design of Novel Amphiphiles with Antibacterial Properties Against MSRA

Tyuleva, Stilyana N., Allen, Nyasha, White, Lisa J., Pepes, Antigoni, Shepherd, H.J., Saines, P.J., Ellaby, Rebecca J., Mulvihill, Daniel P., Hiscock, Jennifer R. (2019) A Symbiotic Supramolecular Approach to the Design of Novel Amphiphiles with Antibacterial Properties Against MSRA. Chemical Communications, 55 . pp. 95-98. ISSN 1359-7345. (doi:10.1039/C8CC08485H) (KAR id:70529)

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Abstract

Herein, we identify Supramolecular Self-associating Amphiphiles (SSAs) as a novel class of antibacterials with activity towards Methicillin-resistant Staphylococcus aureus. Structure-activity relationships have been identified in the solid, solution and gas phases. Finally, we show that when supplied in combination, SSAs exhibit increased antibacterial efficacy against these clinically relevant microbes.

Item Type: Article
DOI/Identification number: 10.1039/C8CC08485H
Subjects: Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Q Science > QD Chemistry > QD473 Physical properties in relation to structure
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Divisions > Division of Natural Sciences > School of Physical Sciences
Depositing User: Jennifer Hiscock
Date Deposited: 30 Nov 2018 18:52 UTC
Last Modified: 16 Feb 2021 13:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/70529 (The current URI for this page, for reference purposes)
Shepherd, H.J.: https://orcid.org/0000-0003-0832-4475
Saines, P.J.: https://orcid.org/0000-0002-4207-2112
Mulvihill, Daniel P.: https://orcid.org/0000-0003-2502-5274
Hiscock, Jennifer R.: https://orcid.org/0000-0002-1406-8802
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