A Symbiotic Supramolecular Approach to the Design of Novel Amphiphiles with Antibacterial Properties Against MSRA

Tyuleva, Stilyana N. and Allen, Nyasha and White, Lisa J. and Pepes, Antigoni and Shepherd, H.J. and Saines, P.J. and Ellaby, Rebecca J. and Mulvihill, Daniel P. and Hiscock, Jennifer R. (2018) A Symbiotic Supramolecular Approach to the Design of Novel Amphiphiles with Antibacterial Properties Against MSRA. Chemical Communications, 55 (95). ISSN 1359-7345. (doi:https://doi.org/10.1039/C8CC08485H) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

PDF - Publisher pdf

Creative Commons Licence
This work is licensed under a Creative Commons Attribution 4.0 International License.
Download (1MB) Preview
[img]
Preview
PDF - Author's Accepted Manuscript
Restricted to Repository staff only
Contact us about this Publication Download (621kB)
[img]
MS Office Open XML (OOXML) - Author's Accepted Manuscript
Restricted to Repository staff only
Contact us about this Publication Download (4MB)
[img]
Official URL
http://dx.doi.org/10.1039/C8CC08485H

Abstract

Herein, we identify Supramolecular Self-associating Amphiphiles (SSAs) as a novel class of antibacterials with activity towards Methicillin-resistant Staphylococcus aureus. Structure-activity relationships have been identified in the solid, solution and gas phases. Finally, we show that when supplied in combination, SSAs exhibit increased antibacterial efficacy against these clinically relevant microbes.

Item Type: Article
Subjects: Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Q Science > QD Chemistry > QD473 Physical properties in relation to structure
Divisions: Faculties > Sciences > School of Biosciences
Faculties > Sciences > School of Biosciences > Cell & Developmental Biology Group
Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Jennifer Hiscock
Date Deposited: 30 Nov 2018 18:52 UTC
Last Modified: 15 Mar 2019 15:56 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/70529 (The current URI for this page, for reference purposes)
Mulvihill, Daniel P.: https://orcid.org/0000-0003-2502-5274
  • Depositors only (login required):

Downloads

Downloads per month over past year