A Symbiotic Supramolecular Approach to the Design of Novel Amphiphiles with Antibacterial Properties Against MSRA

Tyuleva, Stilyana N., Allen, Nyasha, White, Lisa J., Pepes, Antigoni, Shepherd, H.J., Saines, P.J., Ellaby, Rebecca J., Mulvihill, Daniel P., Hiscock, Jennifer R. (2019) A Symbiotic Supramolecular Approach to the Design of Novel Amphiphiles with Antibacterial Properties Against MSRA. Chemical Communications, 55 . pp. 95-98. ISSN 1359-7345. (doi:10.1039/C8CC08485H) (KAR id:70529)

PDF Publisher pdf Language: English This work is licensed under a Creative Commons Attribution 4.0 International License.
Download this file (PDF/1MB)
Request a format suitable for use with assistive technology e.g. a screenreader
PDF Author's Accepted Manuscript Language: English Restricted to Repository staff only

XML Word Processing Document (DOCX) Author's Accepted Manuscript Language: English Restricted to Repository staff only

Official URL: http://dx.doi.org/10.1039/C8CC08485H

Abstract

Herein, we identify Supramolecular Self-associating Amphiphiles (SSAs) as a novel class of antibacterials with activity towards Methicillin-resistant Staphylococcus aureus. Structure-activity relationships have been identified in the solid, solution and gas phases. Finally, we show that when supplied in combination, SSAs exhibit increased antibacterial efficacy against these clinically relevant microbes.

Item Type:	Article
DOI/Identification number:	10.1039/C8CC08485H
Subjects:	Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids Q Science > QD Chemistry > QD473 Physical properties in relation to structure
Institutional Unit:	Schools > School of Natural Sciences > Biosciences Schools > School of Engineering, Mathematics and Physics > Physics and Astronomy
Former Institutional Unit:	Divisions > Division of Natural Sciences > Biosciences Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User:	Jennifer Hiscock
Date Deposited:	30 Nov 2018 18:52 UTC
Last Modified:	22 Jul 2025 09:00 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/70529 (The current URI for this page, for reference purposes)

University of Kent Author Information

Shepherd, H.J..

Creator's ORCID:	https://orcid.org/0000-0003-0832-4475
CReDIT Contributor Roles:

Saines, P.J..

Creator's ORCID:	https://orcid.org/0000-0002-4207-2112
CReDIT Contributor Roles:

Mulvihill, Daniel P..

Creator's ORCID:	https://orcid.org/0000-0003-2502-5274
CReDIT Contributor Roles:

Hiscock, Jennifer R..

Creator's ORCID:	https://orcid.org/0000-0002-1406-8802
CReDIT Contributor Roles:

Depositors only (login required):

Altmetric

Total Views

Total unique views of this page since July 2020. For more details click on the image.