Multilevel Regulation and Translational Switches in Synthetic Biology

Kopniczky, Margarita B., Moore, Simon J., Freemont, Paul S. (2015) Multilevel Regulation and Translational Switches in Synthetic Biology. IEEE Transactions on Biomedical Circuits and Systems, 9 (4). pp. 485-496. ISSN 1932-4545. (doi:10.1109/TBCAS.2015.2451707) (KAR id:69455)

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Official URL: https://doi.org/10.1109/TBCAS.2015.2451707

Abstract

In contrast to the versatility of regulatory mechanisms in natural systems, synthetic genetic circuits have been so far predominantly composed of transcriptionally regulated modules.Thisisabouttochangeastherepertoireoffoundational tools for post-transcriptional regulation is quickly expanding. We provide an overview of the different types of translational regulators: protein, small molecule and ribonucleic acid (RNA) responsive and we describe the new emerging circuit designs utilizing these tools. There are several advantages of achieving multilevel regulation via translational switches and it is likely that such designs will have the greatest and earliest impact in mammalian synthetic biology for regenerative medicine and gene therapy applications.

Item Type:	Article
DOI/Identification number:	10.1109/TBCAS.2015.2451707
Uncontrolled keywords:	Biomedical engineering, circuit design, logic devices, protein, ribonucleic acid (RNA), riboswitch, synthetic biology, translation
Subjects:	Q Science
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Simon Moore
Date Deposited:	09 Oct 2018 10:52 UTC
Last Modified:	29 May 2019 21:15 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/69455 (The current URI for this page, for reference purposes)

University of Kent Author Information

Moore, Simon J..

Creator's ORCID:	https://orcid.org/0000-0002-1968-206X
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