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Recent insights on Alzheimer’s disease originating from yeast models

Dan Mulvihill, Dan, Seynnaeve, David, Vecchio, Mara Del, Fruhmann, Gernot, Jimmy, Beckers, Joke, Verelst, Melody, Cools, Joris, Winderickx, Vanessa, Franssens (2018) Recent insights on Alzheimer’s disease originating from yeast models. International Journal of Molecular Sciences, 19 (7). p. 1947. ISSN 1422-0067. (doi:10.3390/ijms19071947)

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In this review article, yeast model-based research advances regarding the role of Amyloid-? (A?), Tau and frameshift Ubiquitin UBB+1 in Alzheimer’s disease (AD) are discussed. Despite having limitations with regard to intercellular and cognitive AD aspects, these models have clearly shown their added value as a complementary model for the study of the molecular aspects of these proteins, including their interplay with AD related cellular processes such as mitochondrial dysfunction and altered proteostasis. Moreover, these yeast models have also shown their importance in translational research, e.g. in compound screenings and for AD diagnostics development. In addition to well-established Saccharomyces cerevisiae models, new upcoming Schizosaccharomyces pombe, Candida glabrata and Kluyveromyces lactis yeast models for A? and Tau are briefly described. Finally, traditional and more innovative research methodologies, e.g. for studying protein oligomerization/aggregation, are highlighted.

Item Type: Article
DOI/Identification number: 10.3390/ijms19071947
Uncontrolled keywords: Alzheimer’s disease; yeast; Tau; Amyloid ?; Ubiquitin; aggregation; oligomerization; prion
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Dan Mulvihill
Date Deposited: 02 Jul 2018 08:43 UTC
Last Modified: 29 May 2019 20:42 UTC
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