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Recent insights on Alzheimer’s disease originating from yeast models

Dan Mulvihill, Dan, Seynnaeve, David, Vecchio, Mara Del, Fruhmann, Gernot, Jimmy, Beckers, Joke, Verelst, Melody, Cools, Joris, Winderickx, Vanessa, Franssens (2018) Recent insights on Alzheimer’s disease originating from yeast models. International Journal of Molecular Sciences, 19 (7). Article Number 1947. ISSN 1422-0067. (doi:10.3390/ijms19071947) (KAR id:67545)

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In this review article, yeast model-based research advances regarding the role of Amyloid-? (A?),

Tau and frameshift Ubiquitin UBB+1 in Alzheimer’s disease (AD) are discussed. Despite having

limitations with regard to intercellular and cognitive AD aspects, these models have clearly shown

their added value as a complementary model for the study of the molecular aspects of these

proteins, including their interplay with AD related cellular processes such as mitochondrial

dysfunction and altered proteostasis. Moreover, these yeast models have also shown their

importance in translational research, e.g. in compound screenings and for AD diagnostics

development. In addition to well-established Saccharomyces cerevisiae models, new upcoming

Schizosaccharomyces pombe, Candida glabrata and Kluyveromyces lactis yeast models for A? and Tau are

briefly described. Finally, traditional and more innovative research methodologies, e.g. for studying

protein oligomerization/aggregation, are highlighted.

Item Type: Article
DOI/Identification number: 10.3390/ijms19071947
Uncontrolled keywords: Alzheimer’s disease; yeast; Tau; Amyloid ?; Ubiquitin; aggregation; oligomerization; prion
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Daniel Mulvihill
Date Deposited: 02 Jul 2018 08:43 UTC
Last Modified: 22 Sep 2020 16:01 UTC
Resource URI: (The current URI for this page, for reference purposes)
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