Recent insights on Alzheimer’s disease originating from yeast models

In this review article, yeast model-based research advances regarding the role of Amyloid-? (A?),

Tau and frameshift Ubiquitin UBB+1 in Alzheimer’s disease (AD) are discussed. Despite having

limitations with regard to intercellular and cognitive AD aspects, these models have clearly shown

their added value as a complementary model for the study of the molecular aspects of these

proteins, including their interplay with AD related cellular processes such as mitochondrial

dysfunction and altered proteostasis. Moreover, these yeast models have also shown their

importance in translational research, e.g. in compound screenings and for AD diagnostics

development. In addition to well-established Saccharomyces cerevisiae models, new upcoming

Schizosaccharomyces pombe, Candida glabrata and Kluyveromyces lactis yeast models for A? and Tau are

briefly described. Finally, traditional and more innovative research methodologies, e.g. for studying

protein oligomerization/aggregation, are highlighted.