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Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs

O'Connor, Rebecca, Romanov, Michael N, Kiazim, Lucas G, Barrett, Paul M, Farré, Marta, Damas, Joana, Ferguson-Smith, Malcolm A., Valenzuela, Nicole, Larkin, Denis M, Griffin, Darren K. and others. (2018) Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs. Nature Communications, 9 (1). Article Number 1883. ISSN 2041-1723. (doi:10.1038/s41467-018-04267-9) (KAR id:67102)

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http://dx.doi.org/10.1038/s41467-018-04267-9

Abstract

Genomic organisation of extinct lineages can be inferred from extant chromosome-level genome assemblies. Here, we apply bioinformatic and molecular cytogenetic approaches to determine the genomic structure of the diapsid common ancestor. We then infer the events that likely occurred along this lineage from theropod dinosaurs through to modern birds. Our results suggest that most elements of a typical ‘avian-like’ karyotype (40 chromosome pairs,

including 30 microchromosomes) were in place before the divergence of turtles from birds ~255 mya. This genome organisation therefore predates the emergence of early dinosaurs and pterosaurs and the evolution of flight. Remaining largely unchanged interchromosomally through the dinosaur–theropod route that led to modern birds, intrachromosomal changes nonetheless reveal evolutionary breakpoint regions enriched for genes with ontology terms related to chromatin organisation and transcription. This genomic structure therefore appears highly stable yet contributes to a large degree of phenotypic diversity, as well as underpinning adaptive responses to major environmental disruptions via intrachromosomal repatterning.

Item Type: Article
DOI/Identification number: 10.1038/s41467-018-04267-9
Projects: [UNSPECIFIED] BB/K008161/1 to D.K.G.
[UNSPECIFIED] BB/K008226/1 to D.M.L.
[UNSPECIFIED] BB/J010170/1 to D.M.L.
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH324.2 Computational biology
Q Science > QH Natural history > QH426 Genetics
Q Science > QL Zoology
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Signature Themes: Food Systems, Natural Resources and Environment
Depositing User: Mike Romanov
Date Deposited: 22 May 2018 14:34 UTC
Last Modified: 12 Jul 2021 17:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/67102 (The current URI for this page, for reference purposes)
O'Connor, Rebecca: https://orcid.org/0000-0002-4270-970X
Romanov, Michael N: https://orcid.org/0000-0003-3584-4644
Farré, Marta: https://orcid.org/0000-0001-9170-5767
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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