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Towards the prediction of global solution state properties for hydrogen bonded, self-associating amphiphiles

White, Lisa J., Tyuleva, Stilyana N., Wilson, Ben, Shepherd, H.J., Ng, Kendrick K. L., Holder, Simon J., Clark, Ewan R., Hiscock, Jennifer R. (2018) Towards the prediction of global solution state properties for hydrogen bonded, self-associating amphiphiles. Chemistry - A European Journal, 24 (30). pp. 7761-7773. ISSN 0947-6539. E-ISSN 1521-3765. (doi:10.1002/chem.201801280)

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Abstract

Through this extensive structure-property study we show that critical micelle concentration correlates with self-associative hydrogen bond complex formation constant, when combined with outputs from low level, widely accessible, computational models. Herein, we bring together a series of 39 structurally related molecules obtained through stepwise variation of a hydrogen bond donor-acceptor amphiphilic salt. The self-associative and corresponding global properties for this family of compounds have been studied in the gas, solid and solution states. Within the solution state we have shown the type of self-associated structure present to be solvent dependent. In DMSO, this class of compound show a preference for hydrogen bonded dimer formation, however moving into aqueous solutions the same compounds are found to form larger self-associated aggregates. This observation has allowed us the unique opportunity to investigate and begin to predict selfassociation events at both the molecular and extended aggregate level.

Item Type: Article
DOI/Identification number: 10.1002/chem.201801280
Subjects: Q Science
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Jennifer Hiscock
Date Deposited: 06 Apr 2018 09:53 UTC
Last Modified: 12 Jul 2019 10:51 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66639 (The current URI for this page, for reference purposes)
Shepherd, H.J.: https://orcid.org/0000-0003-0832-4475
Holder, Simon J.: https://orcid.org/0000-0001-8977-9257
Clark, Ewan R.: https://orcid.org/0000-0001-7287-2631
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