Yasinska, Inna M., Ceccone, Giacomo, Ojea-Jimenez, Isaac, Ponti, Jessica, Hussain, Rohanah, Siligardi, Giuliano, Berger, Steffen M., Fasler-Kan, Elizaveta, Bardelli, Marco, Varani, Luca, and others. (2018) Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates. Nanoscale, 10 (13). pp. 5827-5833. ISSN 2040-3364. E-ISSN 2040-3372. (doi:10.1039/C7NR09436A) (KAR id:66542)
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| Official URL: https://doi.org/10.1039/C7NR09436A |
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Abstract
In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1039/C7NR09436A |
| Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
| Depositing User: | Vadim Sumbayev |
| Date Deposited: | 26 Mar 2018 15:48 UTC |
| Last Modified: | 12 Jan 2023 11:38 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/66542 (The current URI for this page, for reference purposes) |
| Sumbayev, Vadim V.: |  https://orcid.org/0000-0002-9404-5626 |
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