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Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

Yasinska, Inna M., Ceccone, Giacomo, Ojea-Jimenez, Isaac, Ponti, Jessica, Hussain, Rohanah, Siligardi, Giuliano, Berger, Steffen M., Fasler-Kan, Elizaveta, Bardelli, Marco, Varani, Luca, and others. (2018) Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates. Nanoscale, 10 (13). pp. 5827-5833. ISSN 2040-3364. E-ISSN 2040-3372. (doi:10.1039/C7NR09436A) (KAR id:66542)

Abstract

In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.

Item Type: Article
DOI/Identification number: 10.1039/C7NR09436A
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Vadim Sumbayev
Date Deposited: 26 Mar 2018 15:48 UTC
Last Modified: 26 Jan 2024 22:55 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66542 (The current URI for this page, for reference purposes)

University of Kent Author Information

Yasinska, Inna M..

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Sumbayev, Vadim V..

Creator's ORCID: https://orcid.org/0000-0002-9404-5626
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