Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

Yasinska, Inna M., Ceccone, Giacomo, Ojea-Jimenez, Isaac, Ponti, Jessica, Hussain, Rohanah, Siligardi, Giuliano, Berger, Steffen M., Fasler-Kan, Elizaveta, Bardelli, Marco, Varani, Luca, and others. (2018) Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates. Nanoscale, 10 (13). pp. 5827-5833. ISSN 2040-3364. E-ISSN 2040-3372. (doi:10.1039/C7NR09436A) (KAR id:66542)

PDF Publisher pdf Language: English This work is licensed under a Creative Commons Attribution 4.0 International License.
Download this file (PDF/2MB)	Preview
Request a format suitable for use with assistive technology e.g. a screenreader
PDF Author's Accepted Manuscript Language: English
Download this file (PDF/681kB)	Preview
Request a format suitable for use with assistive technology e.g. a screenreader
Official URL: https://doi.org/10.1039/C7NR09436A

Abstract

In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.

Item Type:	Article
DOI/Identification number:	10.1039/C7NR09436A
Institutional Unit:	Schools > Medway School of Pharmacy
Former Institutional Unit:	Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User:	Vadim Sumbayev
Date Deposited:	26 Mar 2018 15:48 UTC
Last Modified:	22 Jul 2025 08:59 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/66542 (The current URI for this page, for reference purposes)

University of Kent Author Information

Yasinska, Inna M..

Creator's ORCID:
CReDIT Contributor Roles:

Sumbayev, Vadim V..

Creator's ORCID:	https://orcid.org/0000-0002-9404-5626
CReDIT Contributor Roles:

Depositors only (login required):

Altmetric

Total Views

Total unique views of this page since July 2020. For more details click on the image.