Skip to main content

Asenjonamides A–C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Abdelkader, Mohamed S. A., Philippon, Thomas, Asenjo, Juan A., Bull, Alan T., Goodfellow, Michael, Ebel, Rainer, Jaspars, Marcel, Rateb, Mostafa E. (2018) Asenjonamides A–C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil. The Journal of Antibiotics, . ISSN 0021-8820. E-ISSN 1881-1469). (doi:10.1038/s41429-017-0012-0)

PDF - Author's Accepted Manuscript
Download (275kB) Preview
[img]
Preview
Official URL
https://doi.org/10.1038/s41429-017-0012-0

Abstract

Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive ?-diketones; asenjonamides A–C (1–3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-?-N-glycosides; spicamycins A–E (5–9), and seven known diketopiperazines (10–16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

Item Type: Article
DOI/Identification number: 10.1038/s41429-017-0012-0
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 29 Jan 2018 12:12 UTC
Last Modified: 30 Aug 2019 14:15 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/65804 (The current URI for this page, for reference purposes)
Bull, Alan T.: https://orcid.org/0000-0001-6223-7722
  • Depositors only (login required):

Downloads

Downloads per month over past year