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Characterization of metabolic responses to healthy diets and the association with blood pressure: application to the Optimal Macronutrient Intake Trial for Heart Health (OmniHeart), a Randomized Control Study

Loo, Ruey Leng, Xin, Zou, Appel, Lawrence, Nicholson, Jeremy K., Holmes, Elaine (2018) Characterization of metabolic responses to healthy diets and the association with blood pressure: application to the Optimal Macronutrient Intake Trial for Heart Health (OmniHeart), a Randomized Control Study. Characterization of metabolic responses to healthy diets and the association with blood pressure: application to the Optimal Macronutrient Intake Trial for Heart Health (OmniHeart), a Randomized Control Study, 107 (3). pp. 323-334. ISSN 0002-9165. E-ISSN 1938-3207. (doi:10.1093/ajcn/nqx072) (KAR id:65733)

Abstract

Background: Inter-individual variation in the response to diet is common but the underlying mechanism for such variation is unclear.

Design: 24-h urine samples from 158 participants, with pre-hypertension and stage 1 hypertension collected at baseline and following the consumption of a carbohydrate-rich, a protein-rich and a monounsaturated fat-rich healthy diet (6-weeks per diet) in a randomized, crossover study, were analyzed by proton (1H) nuclear magnetic resonance (NMR) spectroscopy. Urinary metabolite profiles were interrogated to identify typical and variable responses to each diet. We quantified the differences in absolute excretion of metabolites distinguishing between dietary comparisons within the typical response groups and established their associations with CVD risk factors using linear regression.

Conclusion: These data indicate inter-individual variations in BP in response to dietary change and highlight the potential influence of the gut microbiome in mediating this relationship. This approach provides a framework for stratification of individuals undergoing dietary management.

Item Type: Article
DOI/Identification number: 10.1093/ajcn/nqx072
Uncontrolled keywords: diets; gut microbiome; hypertension; metabolic profiling, metabonomic, metabolomic; and personalized health care.
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Rueyleng Loo
Date Deposited: 30 Jan 2018 13:21 UTC
Last Modified: 29 May 2019 20:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/65733 (The current URI for this page, for reference purposes)
Loo, Ruey Leng: https://orcid.org/0000-0001-5307-5709
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