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Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine

Krstulja, Aleksandra, Lettieri, Stefania, Hall, Andrew J., Roy, Vincent, Favetta, Patrick, Agrofoglio, Luigi A. (2017) Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine. Macromolecular Bioscience, 17 (12). ISSN 1616-5187. (doi:10.1002/mabi.201700250)

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Abstract

Pseudouridine (?) is an important urinary cancer biomarker, especially in human colorectal cancer (CRC). Disclosed herein is the first ? molecularly imprinted polymer (?-MIP) material obtained from tailor-engineered functional monomers. The resulting MIP imprint exhibits a remarkable imprinting factor greater than 70. It is successfully used for the selective recognition of ? in spiked human urine. This selective functionalized material opens the route to the development of inexpensive disposable chemosensors for noninvasive CRC diagnosis and prognosis.

Item Type: Article
DOI/Identification number: 10.1002/mabi.201700250
Uncontrolled keywords: pseudouridine, tailor-made monomer, molecular recognition, imprinted polymer, cancer
Subjects: Q Science > QD Chemistry
Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Q Science > QD Chemistry > Analytical Chemistry
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Andrew Hall
Date Deposited: 17 Nov 2017 09:03 UTC
Last Modified: 29 May 2019 19:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/64514 (The current URI for this page, for reference purposes)
Hall, Andrew J.: https://orcid.org/0000-0001-8849-7063
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