Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine

Krstulja, Aleksandra and Lettieri, Stefania and Hall, Andrew J. and Roy, Vincent and Favetta, Patrick and Agrofoglio, Luigi A. (2017) Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine. Macromolecular Bioscience, 17 (12). ISSN 1616-5187. (doi:https://doi.org/10.1002/mabi.201700250) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Pseudouridine (?) is an important urinary cancer biomarker, especially in human colorectal cancer (CRC). Disclosed herein is the first ? molecularly imprinted polymer (?-MIP) material obtained from tailor-engineered functional monomers. The resulting MIP imprint exhibits a remarkable imprinting factor greater than 70. It is successfully used for the selective recognition of ? in spiked human urine. This selective functionalized material opens the route to the development of inexpensive disposable chemosensors for noninvasive CRC diagnosis and prognosis.

Item Type: Article
Uncontrolled keywords: pseudouridine, tailor-made monomer, molecular recognition, imprinted polymer, cancer
Subjects: Q Science > QD Chemistry
Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Q Science > QD Chemistry > Analytical Chemistry
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Andrew Hall
Date Deposited: 17 Nov 2017 09:03 UTC
Last Modified: 16 Nov 2018 00:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/64514 (The current URI for this page, for reference purposes)
Hall, Andrew J.: https://orcid.org/0000-0001-8849-7063
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