Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine

Krstulja, Aleksandra, Lettieri, Stefania, Hall, Andrew J., Roy, Vincent, Favetta, Patrick, Agrofoglio, Luigi A. (2017) Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine. Macromolecular Bioscience, 17 (12). Article Number 1700250. ISSN 1616-5187. (doi:10.1002/mabi.201700250) (KAR id:64514)

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Official URL: http://dx.doi.org/10.1002/mabi.201700250

Abstract

Pseudouridine (?) is an important urinary cancer biomarker, especially in human colorectal cancer (CRC). Disclosed herein is the first ? molecularly imprinted polymer (?-MIP) material obtained from tailor-engineered functional monomers. The resulting MIP imprint exhibits a remarkable imprinting factor greater than 70. It is successfully used for the selective recognition of ? in spiked human urine. This selective functionalized material opens the route to the development of inexpensive disposable chemosensors for noninvasive CRC diagnosis and prognosis.

Item Type:	Article
DOI/Identification number:	10.1002/mabi.201700250
Uncontrolled keywords:	pseudouridine, tailor-made monomer, molecular recognition, imprinted polymer, cancer
Subjects:	Q Science > QD Chemistry Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids Q Science > QD Chemistry > Analytical Chemistry
Institutional Unit:	Schools > Medway School of Pharmacy
Former Institutional Unit:	Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User:	Andrew Hall
Date Deposited:	17 Nov 2017 09:03 UTC
Last Modified:	20 May 2025 09:55 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/64514 (The current URI for this page, for reference purposes)

University of Kent Author Information

Hall, Andrew J..

Creator's ORCID:	https://orcid.org/0000-0001-8849-7063
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