Skip to main content

A Review of the Human Sigma-1 Receptor Structure

Ossa, Felipe, Schnell, Jason R, Ortega-Roldan, Jose L. (2017) A Review of the Human Sigma-1 Receptor Structure. Advances in experimental medicine and biology, 964 . pp. 15-29. ISSN 0065-2598. (doi:10.1007/978-3-319-50174-1_3) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:61304)

PDF Publisher pdf
Language: English

Restricted to Repository staff only

Contact us about this Publication
[thumbnail of 10.1007-978-3-319-50174-1_3.pdf]
Official URL:
http://dx.doi.org/10.1007/978-3-319-50174-1_3

Abstract

The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential. Newly reported structures of the human S1R in ligand-bound states provides essential insights into small molecule binding in the context of the overall protein structure. The structure also raises many interesting questions and provides an excellent starting point for understanding the molecular tricks employed by this small membrane receptor to modulate a large number of signaling events. Here, we review insights from the structures of ligand-bound S1R in the context of previous biochemical studies and propose, from a structural viewpoint, a set of important future directions.

Item Type: Article
DOI/Identification number: 10.1007/978-3-319-50174-1_3
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Jose Ortega Roldan
Date Deposited: 31 Jul 2017 13:53 UTC
Last Modified: 29 May 2019 18:56 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/61304 (The current URI for this page, for reference purposes)

University of Kent Author Information

Ortega-Roldan, Jose L..

Creator's ORCID: https://orcid.org/0000-0002-6316-4390
CReDIT Contributor Roles:
  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.