Lee, M O, Romanov, Michael N, Plemyashov, Kirill V, Dementieva, N V, Mitrofanova, O V, Barkova, O Yu, Womack, J E (2017) Haplotype structure and copy number polymorphism of the beta-defensin 7 genes in diverse chicken breeds. Animal Genetics, 48 (4). pp. 490-492. ISSN 0268-9146. E-ISSN 1365-2052. (doi:10.1111/age.12552)
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| Official URL http://dx.doi.org/10.1111/age.12552 |
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Abstract
Beta-defensins is a family of avian peptides related to the innate immune system. Copy number variation was recently reported for the avian beta-defensin 7 gene (AvBD7) between the highly inbred Leghorn and Fayoumi lines. Here, we examined copy number variants in 35 different chicken breeds and found that 31 of them have at least the same representation of the duplicated AvBD7 allele. We also found haplotypes upstream of the AvBD6 regions that are strongly linked to the AvBD7 duplication. We observed a strong linkage disequilibrium spanning of the upstream region of the AvBD6 gene, with two SNPs being flanking markers to detect duplication of the AvBD7.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1111/age.12552 |
| Uncontrolled keywords: | copy number variants, haplotype, linkage disequilibrium, poultry breeds |
| Subjects: | Q Science > QH Natural history > QH426 Genetics |
| Divisions: | Faculties > Sciences > School of Biosciences > Biomedical Research Group |
| Depositing User: | M. Romanov |
| Date Deposited: | 08 Apr 2017 06:57 UTC |
| Last Modified: | 29 May 2019 18:56 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/61284 (The current URI for this page, for reference purposes) |
| Romanov, Michael N: |  https://orcid.org/0000-0003-3584-4644 |
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