Lee, M O, Romanov, Michael N, Plemyashov, Kirill V, Dementieva, N V, Mitrofanova, O V, Barkova, O Yu, Womack, J E (2017) Haplotype structure and copy number polymorphism of the beta-defensin 7 genes in diverse chicken breeds. Animal Genetics, 48 (4). pp. 490-492. ISSN 0268-9146. E-ISSN 1365-2052. (doi:10.1111/age.12552) (KAR id:61284)
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Official URL: http://dx.doi.org/10.1111/age.12552 |
Abstract
Beta-defensins is a family of avian peptides related to the innate immune system. Copy number variation was recently reported for the avian beta-defensin 7 gene (AvBD7) between the highly inbred Leghorn and Fayoumi lines. Here, we examined copy number variants in 35 different chicken breeds and found that 31 of them have at least the same representation of the duplicated AvBD7 allele. We also found haplotypes upstream of the AvBD6 regions that are strongly linked to the AvBD7 duplication. We observed a strong linkage disequilibrium spanning of the upstream region of the AvBD6 gene, with two SNPs being flanking markers to detect duplication of the AvBD7.
Item Type: | Article |
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DOI/Identification number: | 10.1111/age.12552 |
Projects: | Development of the Methodology of Genomic Selection for the Conservation and Effective Use of the Potential of Genetic Resources, and Creation of Highly Productive Strains in the Poultry Industry of Russia, Development of State-of-the-Art Biotechnologies to Assess Gene Expression in Relation to Performance and Disease Resistance in Poultry Industry |
Uncontrolled keywords: | copy number variants, haplotype, linkage disequilibrium, poultry breeds |
Subjects: | Q Science > QH Natural history > QH426 Genetics |
Divisions: | Divisions > Division of Natural Sciences > Biosciences |
Funders: |
[UNSPECIFIED] Russian Science Foundation
[UNSPECIFIED] Ministry of Science and Higher Education of the Russian Federation |
Depositing User: | Mike Romanov |
Date Deposited: | 08 Apr 2017 06:57 UTC |
Last Modified: | 13 Jul 2021 14:47 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/61284 (The current URI for this page, for reference purposes) |
Romanov, Michael N: | ![]() |
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