Whole genome sequencing of California condors is now utilized for guiding genetic management

Ryder, Oliver and Miller, Webb and Ralls, Katherine and Ballou, Jonathan D and Steiner, Cynthia C and Mitelberg, Anna and Romanov, Michael N and Chemnick, Leona G and Mace, Michael and Schuster, Stephan (2016) Whole genome sequencing of California condors is now utilized for guiding genetic management. In: International Plant and Animal Genome XXIV Conference, 8-13 January 2016, San Diego, CA, USA. (Full text available)

Abstract

The California condor is a critically endangered avian species that, in 1982, became extinct in the wild. Its survival has persevered through a captive breeding program and reintroduction efforts within its former range. As of April, 2015, 421 California condors, including 204 flying in the wild constituted the extant population. Concern regarding preservation of genetic diversity and inbreeding, have led to intensive population management supported by molecular genetics research and, more recently, the application of genomic methodologies. 36 complete California condor genomes, representing the whole gene pool of the species, have been sequenced identifying about 4 millions polymorphic sites (SNPs). This has allowed reassessment of kinship among the founder birds, which is now being applied to selecting breeding pairs for the ongoing captive propagation effort. A genetic disease, chondrodystrophy, is inherited consistent with an autosomal recessive mode of transmission in condors. Utilizing whole genome sequencing of affected chicks and their carrier parents, a series of linked markers localized in a 1 Mb region of the condor genome have been employed to detect carrier condors heterozygous for the lethal mutation. This information can be incorporated into population management to reduce the risk of reproductive failure, as reintroduced populations begin to expand.

Item Type: Conference or workshop item (Paper)
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: M. Romanov
Date Deposited: 28 Mar 2017 15:38 UTC
Last Modified: 14 Jan 2019 11:05 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/61072 (The current URI for this page, for reference purposes)
Romanov, Michael N: https://orcid.org/0000-0003-3584-4644
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