Skip to main content

Microfluidic manufacturing of phospholipid nanoparticles: Stability, encapsulation efficacy, and drug release

Guimarães Sá Correia, Mariana, Briuglia, Maria L., Niosi, Fabio, Lamprou, Dimitrios A. (2016) Microfluidic manufacturing of phospholipid nanoparticles: Stability, encapsulation efficacy, and drug release. International Journal of Pharmaceutics, 516 (1-2). pp. 91-99. ISSN 0378-5173. (doi:10.1016/j.ijpharm.2016.11.025)

Abstract

Liposomes have been the centre of attention in research due to their potential to act as drug delivery systems. Although its versatility and manufacturing processes are still not scalable and reproducible. In this study, the microfluidic method for liposomes preparation is presented. DMPC and DSPC liposomes containing two different lipid/cholesterol ratios (1:1 and 2:1) are prepared. Results from this preparation process were compared with the film hydration method in order to understand benefits and drawbacks of microfluidics. Liposomes characterisation was evaluated through stability studies, encapsulation efficacy and drug release profiles of hydrophilic and lipophilic compounds. Stability tests were performed during 3 weeks and the liposomes properties of the most stable formulations were determined using Infrared Microscopy and Atomic Force Microscopy. Microfluidic allows loading of drugs and assembly in a quick single step and the chosen flow ratio for liposomes formulation plays a fundamental role for particle sizes. One hydrophilic and one lipophilic compounds were incorporated showing how formulation and physic-chemical characteristics can influence the drug release profile.

Item Type: Article
DOI/Identification number: 10.1016/j.ijpharm.2016.11.025
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Dimitrios Lamprou
Date Deposited: 06 Mar 2017 16:42 UTC
Last Modified: 01 Aug 2019 10:41 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/59860 (The current URI for this page, for reference purposes)
Lamprou, Dimitrios A.: https://orcid.org/0000-0002-8740-1661
  • Depositors only (login required):

Downloads

Downloads per month over past year