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Filamentous Influenza Viruses

Badham, Matthew D., Rossman, Jeremy S. (2016) Filamentous Influenza Viruses. Current Clinical Microbiology Reports, 3 (3). pp. 155-161. ISSN 2196-5471. (doi:10.1007/s40588-016-0041-7)

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http://dx.doi.org/10.1007/s40588-016-0041-7

Abstract

Influenza A virus is a pathogen of global medical importance causing significant health and socio-economic costs every year. Influenza virus is an unusual pathogen in that it is pleomorphic, capable of forming virions ranging in shape from spherical to filamentous. Despite decades of research on the influenza virus, much remains unknown about the formation of filamentous influenza viruses and their role in the viral replication cycle. Here, we discuss what is known about influenza virus assembly and budding, focusing on the viral and host factors that are involved in the determination of viral morphology. Whilst the biological function of the filamentous morphology remains unknown, recent results suggest a role in facilitating viral spread in vivo. We discuss these results and speculate on the consequences of viral morphology during influenza virus infection of the human respiratory tract

Item Type: Article
DOI/Identification number: 10.1007/s40588-016-0041-7
Uncontrolled keywords: Influenza virus,Morphology,Filaments,Assembly,Budding
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Jeremy Rossman
Date Deposited: 13 Dec 2016 12:54 UTC
Last Modified: 29 May 2019 18:28 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/59661 (The current URI for this page, for reference purposes)
Rossman, Jeremy S.: https://orcid.org/0000-0001-6124-4103
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