Cardioprotection and lifespan extension by the natural polyamine spermidine

Eisenberg, Tobias, Abdellatif, Mahmoud, Schroeder, Sabrina, Primessnig, Uwe, Stekovic, Slaven, Pendl, Tobias, Harger, Alexandra, Schipke, Julia, Zimmermann, Andreas, Schmidt, Albrecht, and others. (2016) Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine, (22). pp. 1428-1438. ISSN 1078-8956. (doi:10.1038/nm.4222) (KAR id:58741)

XML Word Processing Document (DOCX) Other Language: English
Download this file (XML Word Processing Document (DOCX)/13kB)
Request a format suitable for use with assistive technology e.g. a screenreader
PDF Author's Accepted Manuscript Language: English
Download this file (PDF/2MB)	Preview
Request a format suitable for use with assistive technology e.g. a screenreader
Official URL: http://doi.org/10.1038/nm.4222

Abstract

Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.

Item Type:	Article
DOI/Identification number:	10.1038/nm.4222
Subjects:	Q Science Q Science > QP Physiology (Living systems) Q Science > QP Physiology (Living systems) > QP506 Molecular biology Q Science > QP Physiology (Living systems) > QP517 Biochemistry R Medicine R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC667 Diseases of the circulatory (cardiovascular) system
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	P. Rockenfeller
Date Deposited:	18 Nov 2016 11:45 UTC
Last Modified:	05 Nov 2024 10:50 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/58741 (The current URI for this page, for reference purposes)

University of Kent Author Information

Rockenfeller, Patrick.

Creator's ORCID:
CReDIT Contributor Roles:

Depositors only (login required):

Altmetric

Download Statistics

Total unique views for this document in KAR since July 2020. For more details click on the image.