Serpell, C.J., Rutte, R.N., Geraki, K., Pach, E., Martincic, M., Kierkowicz, M., De Munari, S., Wals, K., Raj, R., Ballesteros, B., and others. (2016) Carbon nanotubes allow capture of krypton, barium and lead for multichannel biological X-ray fluorescence imaging. Nature Communications, 7 . Article Number 13118. ISSN 2041-1723. (doi:10.1038/ncomms13118) (KAR id:58527)
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| Official URL: http://dx.doi.org/10.1038/ncomms13118 |
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Abstract
The desire to study biology in situ has been aided by many imaging techniques. Among these, X-ray fluorescence (XRF) mapping permits observation of elemental distributions in a multichannel manner. However, XRF imaging is underused, in part, because of the difficulty in interpreting maps without an underlying cellular ‘blueprint’; this could be supplied using contrast agents. Carbon nanotubes (CNTs) can be filled with a wide range of inorganic materials, and thus can be used as ‘contrast agents’ if biologically absent elements are encapsulated. Here we show that sealed single-walled CNTs filled with lead, barium and even krypton can be produced, and externally decorated with peptides to provide affinity for sub-cellular targets. The agents are able to highlight specific organelles in multiplexed XRF mapping, and are, in principle, a general and versatile tool for this, and other modes of biological imaging.
| Item Type: | Article |
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| DOI/Identification number: | 10.1038/ncomms13118 |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Divisions > Division of Natural Sciences > Physics and Astronomy |
| Depositing User: | Christopher Serpell |
| Date Deposited: | 10 Nov 2016 13:47 UTC |
| Last Modified: | 05 Nov 2024 10:49 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/58527 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Serpell, C.J..
| Creator's ORCID: |
 https://orcid.org/0000-0002-2848-9077
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