Upgrading molecular cytogenetics to study reproduction and reproductive isolation in mammals, birds, and dinosaurs

O'Connor, Rebecca and Damas, J and Farré, Marta and Romanov, Michael N and Martell, Henry and Fonseka, Gothami and Jennings, R and Kiazam, L and Bennett, Sophie and Ward, Jake and Mandawala, A and Joseph, S and Frodsham, Richard and Lawrie, M and Archibald, Alan L. and Walling, Grant A and Fowler, Katie E and Larkin, Denis M and Griffin, Darren K. (2016) Upgrading molecular cytogenetics to study reproduction and reproductive isolation in mammals, birds, and dinosaurs. Cytogenetic and Genome Research, 148 (2–3). 151-152, Abstract VII.13. ISSN 1424-8581. E-ISSN 1424–859X. (Unpublished) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Abstract

The past 10–15 years have seen a revolution in the field of genomics, first with the human genome project, followed by those of key model and agricultural species (chicken, pig, cattle, sheep) and, most recently, ∼ 60 de novo avian genome assemblies. The ultimate aim of a genome assembly is to create a contiguous unbroken length of sequence from p- to q-terminus to facilitate studies of gene mapping, trait linkage, phylogenomics, and gross genomic organization/change. Chromosome rearrangements are biologically relevant both in the context of reduction in reproductive capability of individual animals and in the establishment in reproductive isolation as species evolve and diverge. Moreover, a karyotype effectively represents a low-resolution map of the genome of any species. In investigating all these aspects, FISH remains the tool of choice, and this study describes a step change in its use.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculties > Sciences > School of Biosciences
Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: M. Romanov
Date Deposited: 27 Aug 2016 12:25 UTC
Last Modified: 13 Nov 2018 10:16 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/57004 (The current URI for this page, for reference purposes)
O'Connor, Rebecca: https://orcid.org/0000-0002-4270-970X
Farré, Marta: https://orcid.org/0000-0001-9170-5767
Romanov, Michael N: https://orcid.org/0000-0003-3584-4644
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