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Cell biology. Sowing the protein seeds of prion propagation

Tuite, Mick F. (2000) Cell biology. Sowing the protein seeds of prion propagation. Science, 289 (5479). pp. 556-557. ISSN 0036-8075. (doi:10.1126/science.289.5479.556) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:5460)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1126/science.289.5479.556

Abstract

Ever since Prusiner first proposed his radical "protein-only" hypothesis to explain how certain infectious proteins (prions) are transmitted from one mammal to another in the absence of DNA or RNA, scientists have been trying to prove him right (or wrong). The study of mammalian prions, such as those causing Creutzfeldt-Jakob disease in humans, scrapie in sheep and mad cow disease in cattle, has been slow to yield answers. However, as Tuite discusses in his Perspective, the Sup35p and Ure2p proteins of yeast that exist in both normal and infectious forms are providing evidence that the "protein-only" hypothesis may be right (Sparrer et al.).

Item Type: Article
DOI/Identification number: 10.1126/science.289.5479.556
Additional information: 0036-8075 (Print) Comment Journal Article
Uncontrolled keywords: Biopolymers Fungal Proteins/*chemistry/genetics/metabolism Liposomes Molecular Weight Mutation Phenotype Prions/*chemistry/genetics/metabolism Protein Conformation Saccharomyces cerevisiae/*chemistry/genetics/metabolism *Saccharomyces cerevisiae Proteins
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Michael Tuite
Date Deposited: 27 May 2009 07:08 UTC
Last Modified: 16 Nov 2021 09:43 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/5460 (The current URI for this page, for reference purposes)

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