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[PSI+] turns 50

Tuite, Mick F., Staniforth, Gemma L., Cox, Brian S. (2015) [PSI+] turns 50. Prion, 9 (5). pp. 318-332. ISSN 1933-690X. E-ISSN 1933-690X. (doi:10.1080/19336896.2015.1111508) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:53587)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://doi.org/10.1080/19336896.2015.1111508

Abstract

The year 2015 sees the fiftieth anniversary of the publication of a research paper that underpins much of our understanding of fungal prion biology, namely “?, a cytoplasmic suppressor of super-suppressor in yeast” by Brian Cox. Here we show how our understanding of the molecular nature of the [PSI+] determinant evolved from an ‘occult’ determinant to a transmissible amyloid form of a translation termination factor. We also consider the impact studies on [PSI] have had – and continue to have - on prion research. To demonstrate this, leading investigators in the yeast prion field who have made extensive use of the [PSI+] trait in their research, provide their own commentaries on the discovery and significance of [PSI].

Item Type: Article
DOI/Identification number: 10.1080/19336896.2015.1111508
Uncontrolled keywords: yeast, prion, Brian Cox, non-Mendelian inheritance, [PSI+] prion, nonsense suppression
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Susan Davies
Date Deposited: 05 Jan 2016 11:08 UTC
Last Modified: 06 May 2020 03:14 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/53587 (The current URI for this page, for reference purposes)
Tuite, Mick F.: https://orcid.org/0000-0002-5214-540X
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