Tuite, Mick F., Staniforth, Gemma L., Cox, Brian S. (2015) [PSI+] turns 50. Prion, 9 (5). pp. 318-332. ISSN 1933-690X. E-ISSN 1933-690X. (doi:10.1080/19336896.2015.1111508) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:53587)
The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
Official URL: http://doi.org/10.1080/19336896.2015.1111508 |
Abstract
The year 2015 sees the fiftieth anniversary of the publication of a research paper that underpins much of our understanding of fungal prion biology, namely “?, a cytoplasmic suppressor of super-suppressor in yeast” by Brian Cox. Here we show how our understanding of the molecular nature of the [PSI+] determinant evolved from an ‘occult’ determinant to a transmissible amyloid form of a translation termination factor. We also consider the impact studies on [PSI] have had – and continue to have - on prion research. To demonstrate this, leading investigators in the yeast prion field who have made extensive use of the [PSI+] trait in their research, provide their own commentaries on the discovery and significance of [PSI].
Item Type: | Article |
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DOI/Identification number: | 10.1080/19336896.2015.1111508 |
Uncontrolled keywords: | yeast, prion, Brian Cox, non-Mendelian inheritance, [PSI+] prion, nonsense suppression |
Subjects: | Q Science |
Divisions: | Divisions > Division of Natural Sciences > Biosciences |
Depositing User: | Susan Davies |
Date Deposited: | 05 Jan 2016 11:08 UTC |
Last Modified: | 05 Nov 2024 10:40 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/53587 (The current URI for this page, for reference purposes) |
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