Hamann, Jörg, Aust, Gabriela, Araç, Demet, Engel, Felix B, Formstone, Caroline, Fredriksson, Robert, Hall, Randy A., Harty, Breanne L., Kirchhoff, Christiane, Knapp, Barbara, and others. (2015) International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors. Pharmacological Reviews, 67 (2). pp. 338-367. ISSN 0031-6997. E-ISSN 1521-0081. (doi:10.1124/pr.114.009647) (KAR id:53069)
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| Official URL: http://dx.doi.org/10.1124/pr.114.009647 |
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Abstract
The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.
| Item Type: | Article |
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| DOI/Identification number: | 10.1124/pr.114.009647 |
| Additional information: | For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. |
| Subjects: |
Q Science > QP Physiology (Living systems) Q Science > QP Physiology (Living systems) > QP517 Biochemistry |
| Institutional Unit: | Schools > Medway School of Pharmacy |
| Former Institutional Unit: |
Divisions > Division of Natural Sciences > Medway School of Pharmacy
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| Funders: |
University of Kent (https://ror.org/00xkeyj56)
Wellcome Trust (https://ror.org/029chgv08) Biotechnology and Biological Sciences Research Council (https://ror.org/00cwqg982) |
| Depositing User: | Yuri Ushkarev |
| Date Deposited: | 10 Dec 2015 16:43 UTC |
| Last Modified: | 22 Jul 2025 08:57 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/53069 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Ushkaryov, Yuri A..
| Creator's ORCID: |
 https://orcid.org/0000-0002-5712-8297
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