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Avian cytogenetics goes functional, in: Third Report on Chicken Genes and Chromosomes 2015

Griffin, Darren K., Romanov, Michael N, O'Connor, Rebecca, Fowler, Katie E., Larkin, Denis M. (2015) Avian cytogenetics goes functional, in: Third Report on Chicken Genes and Chromosomes 2015. Cytogenetic and Genome Research, 145 (2). pp. 100-105. ISSN 1424-8581. E-ISSN 1424-859X. (doi:10.1159/000430927) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:49538)

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Abstract

It is now over 10 years since the first avian genome [International Chicken Genome Sequencing Consortium, 2004] and the first complete avian karyotype [Masabanda et al., 2004] were both published; however, until 2014, avian cytogenetics has focused heavily on descriptive studies [e.g. Griffin et al., 2007, 2008; Skinner et al., 2009; Völker et al., 2010] with less attention to its functional relevance. Last year, however, saw 2 landmark efforts in the chromosomal studies of birds: a special issue of Chromosome Research in April and the announcement of recently completed sequences of multiple new avian genomes in Science and the BMC journals (taking the total number sequenced to over 50) in December. Studying the chromosomes of birds is, perhaps for the first time, telling us more about avian biology, function and evolution than it ever has...

Conclusions.

The most recent advances in avian cytogenetics have culminated in great promise not only for the study of bird karyotypes, but also for providing insight into the mechanisms of chromosome evolution in general. New avenues for investigation include gene regulation; for instance, it will become necessary to map accurately the physical location of polyadenylation and transcription start sites, important reference points that define promoters and post-transcriptional regulation. It will also become possible to sequence full-length transcripts, to allow accurate identification of alternate splicing events and their controlling elements. The ENCODE (Encyclopedia of DNA Elements) project has helped to define functional elements of the human genome, including those aforementioned as well as other chromatin signals, e.g. active chromatin, enhancers, insulators, methylation domains, etc. An effort of agENCODE is underway to include agriculturally important birds such as chicken, turkey, duck, quail, and perhaps ostrich. The study of cytogenetics will be essential here in helping to define higher-order structures in nuclear organization that show regulatory interactions within and between chromosomes. Finally, reconstruction of evolutionary events allows us to study genome organization and function not only in extant but, by extrapolation, in extinct species also. Reconstruction of avian-reptilian ancestral karyotypes will allow us to define chromosomal rearrangements in long-dead species that have captured the public imagination. Here be dragons!

Item Type: Article
DOI/Identification number: 10.1159/000430927
Additional information: ISBN 978–3–318–05568–9 e-ISBN 978–3–318–05569–6
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH426 Genetics
Q Science > QL Zoology
Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Signature Themes: Food Systems, Natural Resources and Environment
Depositing User: Mike Romanov
Date Deposited: 15 Jul 2015 13:00 UTC
Last Modified: 30 Jul 2021 11:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/49538 (The current URI for this page, for reference purposes)
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
Romanov, Michael N: https://orcid.org/0000-0003-3584-4644
O'Connor, Rebecca: https://orcid.org/0000-0002-4270-970X
Fowler, Katie E.: https://orcid.org/0000-0003-0359-2390
Larkin, Denis M.: https://orcid.org/0000-0001-7859-6201
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