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Actin - a biosensor that determines cell fate in yeasts.

Smethurst, Daniel G J, Dawes, Ian W, Gourlay, Campbell W (2014) Actin - a biosensor that determines cell fate in yeasts. FEMS yeast research, 14 (1). pp. 89-95. ISSN 1567-1364. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:47014)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)

Abstract

The decision to proliferate, to activate stress response mechanisms or to initiate cell death lies at the heart of the maintenance of a healthy cell population. Within multicellular and colony-forming single-celled organisms, such as yeasts, the functionality of cellular compartments that connect signalling to cell fate must be maintained to maximise adaptability and survival. The actin cytoskeleton is involved in processes such as the regulation of membrane microcompartments, receptor internalisation and the control of master regulatory GTPases, which govern cell decision-making. This affords the actin cytoskeleton a central position within cell response networks. In this sense, a functional actin cytoskeleton is essential to efficiently connect information input to response at the level of the cell. Recent research from fungal, plant and mammalian cells systems has highlighted that actin can trigger apoptotic death in cells that become incompetent to respond to environmental cues. It may also be the case that this property has been appropriated by microorganisms competing for niche environments within a human host. Here, we discuss the research that has been carried out in yeast that links actin to signalling processes and cell fate that supports its role as a biosensor.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Campbell Gourlay
Date Deposited: 30 Jan 2015 11:33 UTC
Last Modified: 29 May 2019 14:10 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/47014 (The current URI for this page, for reference purposes)
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